Leukemia, myeloma and lymphoma

Leukaemia, multiple myeloma (Kahler’s disease), lymphatic cancer and related disorders are among the most prevalent forms of cancer. In the Netherlands approximately 1.500 people are diagnosed with leukaemia and 1.100 patients succumb to the disease. Lymphatic cancer is one of the most prevalent malignant cancers among foreigners. 


Blood and lymphatic cancer presents at any age. There is a peak in children and young adults but the largest number of new patients is between 50 and 80 years of age. The tumours in this last group are nearly always metastatic. The average prognosis of 5 years in patients under 60 with aggressive forms of acute leukaemia and lymphatic cancer is never–the-less 40%. These results can be attributed to invasive therapies such as stem cell transplantation. The results by older patients are less favourable, but new so-called targeted therapy with an immunologic or molecular target is opening prospects for a better future.

Improvement in the dissemination of information, prevention of, and research on these diseases is being addressed in various ways. This takes place in collaboration with the KWF Kankerbestrijding, the intergrated cancer centers, stichting HOVON and patient societies (Stichting Contactgroep Leukemie, Lymfeklierkanker vereniging Nederland, Contactgroep Kahler en Waldenström patiënten, Contactgroep Stamceltransplantatie).

Within Europe there is collaboration with LeukemiaNet, European Myeloma NetworkEuropean Organisation for the Research on Treatment of Cancer (EORTC), European Hematology Association (EHA), European Bone Marrow Transplantation Group (EBMT), Europdonor, EuroCord,European MCL network and Intergroup studies from the HOVON trial network with other groups (among others SAKK and MRC). Besides this there is collaboration with the industry (principally Pharmacology) and participation in Pharmaceutical trials.  

Overview

Contact person

e.braakman@erasmusmc.nl

Main features

Donors

1598

Age cohort

18-92

Phenotypes

Hodgkin lymphoma Follicular lymphoma Non-follicular lymphoma Mature T/NK-cell lymphomas Other and unspecified types of non-Hodgkin lymphoma Other specified types of T/NK-cell lymphoma Malignant immunoproliferative diseases Multiple myeloma and malignant plasma cell neoplasms Lymphoid leukaemia Myeloid leukaemia Monocytic leukaemia Other leukaemias of specified cell type Leukaemia of unspecified cell type Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue

Types of data

Medical records Biological samples

Materials collected

DNA Plasma Serum Urine Feaces Tissue, cryo preserved Tissue, paraffin preserved RNA peripheral blood cells Other

Data enrichment

Genomics